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浙大课题组干细胞研究新成果———让肌腱断裂的小白鼠重新走路
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- 出版日期：
- 2009-04-24
- 正文快照：
- 本报讯，后腿膝盖部髌肌腱断裂的小白鼠，通过植入从胚胎干细胞分阶段分化而来的肌腱后，居然又恢复了正常的活动能力。近日，浙江大学医学院教授欧阳宏伟带领课题组完成的这项研究成果，为治疗肌腱等软组织损伤指出了一条光明大道。相关论文近日发表在目前干细胞领域有着最高影响力的杂志《STEMCELL》（《干细胞》）上。欧阳教授带领的课题组将10至20个胚胎干细胞小团块“铺”在处理过的培养板上进行低密度培养，再做多次克隆、筛选和定性等技术处理。分化后的间质干细胞在特殊培养液中浸泡两个星期后，会形成膜状的间质干细胞片，可被卷成肌腱的形状，再经过一段时间的牵拉、挤压的刺激，就能分化成肌腱细胞正常“工作”，为提高肌腱的修复质量带来新的机会。欧阳宏伟长期从事细胞移植的再生组织器官技术研究，此前他已实现从骨髓中分离出间质干细胞，进行肌腱体外培养再植，而这次是通过胚胎干细胞体外培养再植。欧阳教授介绍说，胚胎干细胞的生长能力和生物特性均优于骨髓间质干细胞，更适用于大批量的培养，在临床应用方面具有更广阔的前景。据悉，由于欧阳宏伟采用了分步诱导等新思路和新技术，还降低了常规实验中因胚胎干细胞分化不全而导致肿瘤形成的风险，实验涉及的所有小白鼠都未发生肿瘤，而肌腱再生质量却大大提高。专业人士认为，这一成果为推进胚胎干细胞走向应用提供了新思路。
- 期次：
- 第321期
- 版次：
- 1
- 来源：
- 浙江大学报
FreeMarker template error (DEBUG mode; use RETHROW in production!):
The following has evaluated to null or missing:
==> showFlag [in template "home/review/reviewCnki.ftl" at line 144, column 6]
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Tip: If the failing expression is known to legally refer to something that's sometimes null or missing, either specify a default value like myOptionalVar!myDefault, or use <#if myOptionalVar??>when-present<#else>when-missing. (These only cover the last step of the expression; to cover the whole expression, use parenthesis: (myOptionalVar.foo)!myDefault, (myOptionalVar.foo)??
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FTL stack trace ("~" means nesting-related):
- Failed at: #if showFlag [in template "home/review/reviewCnki.ftl" at line 144, column 1]
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Java stack trace (for programmers):
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freemarker.core.InvalidReferenceException: [... Exception message was already printed; see it above ...]
at freemarker.core.InvalidReferenceException.getInstance(InvalidReferenceException.java:134)
at freemarker.core.UnexpectedTypeException.newDesciptionBuilder(UnexpectedTypeException.java:85)
at freemarker.core.UnexpectedTypeException.(UnexpectedTypeException.java:48)
at freemarker.core.NonBooleanException.(NonBooleanException.java:47)
at freemarker.core.Expression.modelToBoolean(Expression.java:179)
at freemarker.core.Expression.evalToBoolean(Expression.java:162)
at freemarker.core.Expression.evalToBoolean(Expression.java:147)
at freemarker.core.ConditionalBlock.accept(ConditionalBlock.java:48)
at freemarker.core.Environment.visit(Environment.java:325)
at freemarker.core.Environment.visit(Environment.java:331)
at freemarker.core.Environment.process(Environment.java:304)
at freemarker.template.Template.process(Template.java:382)
at org.springframework.web.servlet.view.freemarker.FreeMarkerView.processTemplate(FreeMarkerView.java:396)
at org.springframework.web.servlet.view.freemarker.FreeMarkerView.doRender(FreeMarkerView.java:309)
at org.springframework.web.servlet.view.freemarker.FreeMarkerView.renderMergedTemplateModel(FreeMarkerView.java:257)
at org.springframework.web.servlet.view.AbstractTemplateView.renderMergedOutputModel(AbstractTemplateView.java:165)
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at org.springframework.web.servlet.DispatcherServlet.render(DispatcherServlet.java:1325)
at org.springframework.web.servlet.DispatcherServlet.processDispatchResult(DispatcherServlet.java:1069)
at org.springframework.web.servlet.DispatcherServlet.doDispatch(DispatcherServlet.java:1008)
at org.springframework.web.servlet.DispatcherServlet.doService(DispatcherServlet.java:925)
at org.springframework.web.servlet.FrameworkServlet.processRequest(FrameworkServlet.java:978)
at org.springframework.web.servlet.FrameworkServlet.doGet(FrameworkServlet.java:870)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:626)
at org.springframework.web.servlet.FrameworkServlet.service(FrameworkServlet.java:855)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:733)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:227)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:53)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.apache.catalina.filters.HttpHeaderSecurityFilter.doFilter(HttpHeaderSecurityFilter.java:126)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.apache.shiro.web.servlet.ProxiedFilterChain.doFilter(ProxiedFilterChain.java:61)
at cnki.tpi.filter.ShiroSsoFilter.doFilter(ShiroSsoFilter.java:70)
at org.apache.shiro.web.servlet.ProxiedFilterChain.doFilter(ProxiedFilterChain.java:66)
at org.apache.shiro.web.servlet.AbstractShiroFilter.executeChain(AbstractShiroFilter.java:449)
at org.apache.shiro.web.servlet.AbstractShiroFilter$1.call(AbstractShiroFilter.java:365)
at org.apache.shiro.subject.support.SubjectCallable.doCall(SubjectCallable.java:90)
at org.apache.shiro.subject.support.SubjectCallable.call(SubjectCallable.java:83)
at org.apache.shiro.subject.support.DelegatingSubject.execute(DelegatingSubject.java:383)
at org.apache.shiro.web.servlet.AbstractShiroFilter.doFilterInternal(AbstractShiroFilter.java:362)
at org.apache.shiro.web.servlet.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:125)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at cnki.tpi.filter.SimpleCORSFilter.doFilter(SimpleCORSFilter.java:28)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.jasig.cas.client.util.HttpServletRequestWrapperFilter.doFilter(HttpServletRequestWrapperFilter.java:75)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.jasig.cas.client.validation.AbstractTicketValidationFilter.doFilter(AbstractTicketValidationFilter.java:201)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at cnki.tpi.filter.SimpleCORSFilter.doFilter(SimpleCORSFilter.java:28)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.springframework.web.filter.RequestContextFilter.doFilterInternal(RequestContextFilter.java:99)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.springframework.web.filter.HttpPutFormContentFilter.doFilterInternal(HttpPutFormContentFilter.java:109)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.springframework.web.filter.HiddenHttpMethodFilter.doFilterInternal(HiddenHttpMethodFilter.java:81)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.springframework.boot.web.servlet.support.ErrorPageFilter.doFilter(ErrorPageFilter.java:115)
at org.springframework.boot.web.servlet.support.ErrorPageFilter.access$000(ErrorPageFilter.java:59)
at org.springframework.boot.web.servlet.support.ErrorPageFilter$1.doFilterInternal(ErrorPageFilter.java:90)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.springframework.boot.web.servlet.support.ErrorPageFilter.doFilter(ErrorPageFilter.java:108)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.springframework.web.filter.CharacterEncodingFilter.doFilterInternal(CharacterEncodingFilter.java:200)
at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:189)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:162)
at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:202)
at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:97)
at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:542)
at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:143)
at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:92)
at org.apache.catalina.valves.AbstractAccessLogValve.invoke(AbstractAccessLogValve.java:687)
at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:78)
at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:357)
at org.apache.coyote.http11.Http11Processor.service(Http11Processor.java:374)
at org.apache.coyote.AbstractProcessorLight.process(AbstractProcessorLight.java:65)
at org.apache.coyote.AbstractProtocol$ConnectionHandler.process(AbstractProtocol.java:893)
at org.apache.tomcat.util.net.NioEndpoint$SocketProcessor.doRun(NioEndpoint.java:1707)
at org.apache.tomcat.util.net.SocketProcessorBase.run(SocketProcessorBase.java:49)
at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1149)
at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:624)
at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61)
at java.lang.Thread.run(Thread.java:748)
